The patient's prolactin level was high when she was treated with risperidone, and the prolactin level dropped by tenfold one week after stopping this medication (from 171.6 to 17.6 ng/mL). These results indicate that paliperidone extended-release 12 mg and risperidone immediate-release 4 mg, administered over a period of 6 days, lead to similar elevations in serum prolactin concentrations. prolactin-related symptoms can occur with amisulpride, risperidone or zotepine with risperidone, increases in prolactin concentration may be comparable to those with therapeutic doses of haloperidol (1) I loved what risperadone did to my brain, but it spiked my prolactin levels so I had to go off of it. I was taking lamotrigine too at the time and didn't find it tipped me high, but I am bipolar 2 so I don't get full blown mania. For those of you that are taking Risperdal or Invega and have high levels of prolactin, adding even a low dose of Abilify to the mix, could decrease prolactin levels by significant amounts. My blood glucose levels were high even on Metformin and my FSH level and TSH thyroid hormone was higher which probably means I have Hypothyroidism. Hyperprolactinaemia With Antipsychotics. Prescriber Update 21: 28-32 May 2001. Medsafe Editorial Team. Dopamine acts on the pituitary as an inhibitor of prolactin secretion. Blockade of dopamine D2 receptors by typical antipsychotics and risperidone can cause hyperprolactinaemia in males and females. Other atypical antipsychotics do not cause sustained hyperprolactinaemia because of their. High prolactin levels can interrupt the normal production of the hormones estrogen and progesterone. This can cause the ovaries to release eggs irregularly or stop altogether. Serum prolactin increases in children and adolescents when risperidone therapy begins, then decreases over time in many patients. When prolactin levels remain elevated, evidence suggests that children may experience adverse effects such as delayed sexual maturation or reduced bone growth because of hypothalamic-pituitary-gonadal axis (HPG. Hyperprolactinaemia is the presence of abnormally high levels of prolactin in the blood. Normal levels are less than 500 mIU/L [20 ng/mL or µg/L] for women, and less than 450 mI U/L for men.